Haynes lab will present research at the 2018 EpiBio Conference

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Cassandra Barrett (Haynes lab PhD student, Biological Design) and Dr. Karmella Haynes will be presenting their latest work at the 2nd Epigenetics and Bioengineering Conference (EpiBio 2018) in San Francisco, CA at the Mission Bay Conference Center on October 4 – 6. The conference is presented by the Society for Biological Engineering (SBE). A great line-up of research talks and posters will include work from engineers and scientists who are applying the discipline of bioengineering to epigenetics. Cassandra Barrett will present a talk entitled “Active versus Accessible: Engineering Open Chromatin in Mammalian Cells.” Dr. Haynes will present a talk on “Histone-Binding Domains as Modules for Custom Fusion Proteins.” Registration is still available online, or attendees can register on site.

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Dr. Haynes invited to speak at Fred Hutchinson Cancer Research Center

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Dr. Haynes has been invited to the Fred Hutchinson Cancer Research Center to present a talk entitled “Investigating the behavior and impact of rationally-designed histone ‘readers’ in the context of cancer epigenomes” for the Current Biology Seminar series on Tuesday, October 2, 2018 in Pelton Auditorium. The seminar will be hosted by the Basic Sciences Division.

Review – CEP – Unlocking access to DNA in chromatin

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Unlocking access to DNA in chromatin
Barrett C and Haynes KA (2018) Chemical Engineering Progress. https://www.aiche.org/resources/publications/cep/2018/september/unlocking-access-dna-chromatin

Since the early 1970’s when scientists first began using bacterial enzymes to cut purified “naked” DNA, scientists have further developed bacterial enzyme-based systems to target and edit specific DNA sequences in eukaryotic hosts, including human cells. However, DNA within eukaryotic cells is not always fully exposed. Instead, it is packed into DNA/protein complexes that form a structure called chromatin. This review highlights new technologies that have enabled scientists to better understand and manipulate the chromosomal structures that impede or enhance access to the underlying DNA.

Haynes Lab members presenting research at the 2018 Fall EBRC Retreat in Colorado

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Haynes lab PhD students Cassandra Barrett and Stefan Tekel, as well as PI Dr. Haynes will present the lab’s latest work in human cell engineering at the 2018 Fall Retreat for the Engineering Biology Research Center (EBRC) at Colorado State University. Dr. Haynes serves on the governing board as a Councilor and has been affiliated with EBRC (formerly SynBERC) since 2011. Cassandra Barrett is the President of the Student and Postdoc Association, and the Policy & International Liaison. Dr. Haynes will present a talk entitled “BifC-PD: Fluorescent Sensors to Illuminate the Impact of Chromatin on the Nuclear Uptake and Expression of Recombinant DNA.” Cassandra Barrett will present a poster entitled “Active versus Accessible: Engineering Open Chromatin in Mammalian Cells.” Stefan Tekel will present a poster entitled “A Versatile Phenotypic Reporter for Cas9 Base Editing of Disease Relevant SNPs,” a collaborative project with the Brafman lab at ASU.

Haynes Lab Alum Spotlight – Rene Daer

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Congratulations to Rene Daer, who recently joined Progenity as a Research Scientist. Rene earned her PhD in Biological Design in 2017 after completing her thesis work in the Haynes lab. Her accomplishments include two first-author research papers in ACS Synthetic Biology and PLoS ONE, a co-authored research paper in Nature Genomic Medicine, a first-author review in Frontiers in Bioengineering, an ARCS award, oral presentations at the biannual SynBERC retreat, and several posters at national conferences. She also served as Co-President of the SynBERC Student and Postdoc Association, co-advisor for the ASU iGEM team, and was a TA for three years for the annual Cold Spring Harbor Summer Course in Synthetic Biology.

Haynes Lab Alum Spotlight – Ben Nyer

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Congratulations to David Ben Nyer, who recently joined Caribou Biosciences as a Research Scientist. Ben was a research technician in the Haynes lab from 2014 – 2017. His accomplishments include first authorship of our paper in Nature Genomic Medicine, a talk at the SynBERC biannual retreat, and poster presentations at national conferences.

News: Synthetic Biology highlighted in ASU News

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Synthetic biology is making an impact at Arizona State University. Articles recently published in the major news outlets for the University describe the recent SEED conference (Synthetic Biology Engineering, Evolution and Design), which took place in Scottsdale, AZ in June 2018. There were over 400 attendees from across the US and the globe. The articles also discuss synthetic biology research taking place in the lab of Dr. Karmella Haynes (SEED 2018 Co-Chair), and the labs of Dr. Xiao Wang, Dr. Samira Kiani (SEED 2018 Co-Chair), David Nielsen, Mo Ebrahimkani (session chair), and Cheryl Nickerson (invited speaker). The articles also feature quotes from Jim Collins (invited speaker, MIT) and Julius Lucks (SEED 2019 Co-Chair, Northwestern U).

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