Synthetic reversal of epigenetic silencing
Haynes KA, Silver PA. (2011) J Biol Chem. 286:27176-82. PMID: 21669865
We developed synthetic gene regulators that interact with epigenetic marks instead of DNA sequences. This research breaks new ground for artificial regulation of genes to stop cancer cell growth. The development of the synthetic chromatin protein marks the beginning of our group’s work in synthetic epigenetics. Cover art was produced by Karmella Haynes.