Synthetic meets Cell Biology
Silver PA, Haynes KA, Weiss R. (2012) Mol. Biol. Cell, 23:967. PMCID: PMC3302743
In 2011 the American Society for Cell Biology Annual Meeting hosted its first minisymposium in Synthetic Cell Biology in Denver, Colorado. This exciting first for the society featured research talks on applying the concepts of synthetic biology to the understanding and engineering of cells.
N. Pierce & J. Kullman, 02.21.2012, ASU News: Haynes, who joined Arizona State University last year as an assistant professor in the School of Biological and Health Systems Engineering, one of ASU’s Ira A. Fulton Schools of Engineering, was recently elected for a two-year term as a Councilor for the Institute of Biological Engineering (IBE).
Read more at ASU News.
A sensitive switch for visualizing natural gene silencing in single cells
Haynes KA, Ceroni F, Flicker D, Younger A, Silver PA. (2012) ACS Synth. Biol. 1: 99–106. PMID: 22530199
We designed a synthetic gene switch that expressed cyan fluorescent protein in the presence of microRNAs, which are biomarkers for cell development and disease. The switch was designed to be sensitive to small, hard-to-detect microRNAs in live cells. Here, we demonstrated that the switch responded to natural as well as artificial proof-of-concept microRNA signals.