Review – Frontiers in Bioengineering – Can the natural diversity of quorum-sensing advance synthetic biology?

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Can the natural diversity of quorum-sensing advance synthetic biology?
Davis RM, Muller RY and Haynes KA (2015) Front. Bioeng. Biotechnol. 3:30. PMID: 25806368.

Quorum sensing takes place when small molecules generated by one bacterium diffuse over to a neighbor and control that neighbor’s genes. With 100 morphologically and genetically distinct species of eubacteria that use quorum sensing to control gene expression, why does the bioengineering community only use about 4 variants to control cell communication? This review explains quorum sensing systems, their use in engineering, the problem of crosstalk between parallel QS systems, and how natural QS diversity might be used to address this problem.

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