Research – Biotechnology & Bioengineering – The histone deacetylase inhibitor Entinostat enhances polymer-mediated transgene expression in cancer cell lines
The histone deacetylase inhibitor entinostat enhances polymer-mediated transgene expression in cancer cell lines
Elmer JJ, Christensen MD, Barua S, Lehrman J, Haynes KA, Rege K. (2015) Biotechnol Bioeng. PMID: 26614912
Collaborators from the Haynes Lab (ASU, SBHSE), Rege Lab (ASU, SEMTE), and Elmer Lab (Villanova) published our discovery of how drugs that modify epigenetic mechanisms improve the expression of synthetic genes that are delivered into cultured human cells. Dr. Elmer is the first author. Dr. Haynes and Matt Christensen (Rege Lab) used quantitative PCR to discover that treatment with a low molecular weight compound called Entinostat led to increased uptake of synthetic DNA into the nuclei of cells.