Dr. Haynes has been invited to present her research at the International Conference on Epigenetics and Bioengineering (EpiBio 2017) in Miami, FL. The conference is presented by the Society of Biological Engineering (SBE). EpiBio 2017 is a forum for engineers and scientists who are applying bioengineering to the area of epigenetics and chromatin. Dr. Haynes will present a talk entitled “Synthetic Readers and Writers of Chromatin to Advance Cell Engineering” on Wednesday, December 13.
Dr. Haynes has been invited to present her group’s latest research on the efficacy of CRISPR editing of human DNA at the 2017 Southeastern Regional Meeting of the ACS (SERMACS) Synthetic Biology Symposium on Thursday, November 9, 2017 in Charlotte, NC. Using a synthetic, regulatable DNA packing system Dr. Haynes and her team, including lead grad student Rene Daer, discovered that chromatin structures similar to those found at stem cell genes can block CRISPR from access to DNA (Daer et al 2017 ACS Synthetic Biology; featured on PRI Science Friday). This can pose a problem for gene therapy and tissue engineering. In her talk “Manipulation of chromatin to enhance CRISPR activity” Dr. Haynes will present a review of these findings as well as recent results from experiments to counteract chromatin and enhance CRISPR activity. The NIH NCI Geographic Management of Cancer Health Disparities Program (GMaP) provided an award to support Dr. Haynes’ travel.
Dr. Haynes has been awarded a mini-grant for RNA-seq analysis of cancer cells that have been treated with a synthetic protein that her group has engineered. Stefan Tekel, a PhD student in the Biological Design Program, is credited for the work that lies at the heart of this project. He engineered a cell-penetrating version of the protein that can be produced at low cost in E. coli bacteria, purified, and then added (as a solution) directly to cancer cells. The group aims to use the RNA-seq to apply for a major grant in the near future.
Haynes lab members Alyssa Henning, Ben Nyer, and Dr. Karmella Haynes will be presenting research at a 2017 Fall Retreat organized by the Engineering Biology Research Consortium (EBRC). The retreat will take place at Georgia Tech in Atlanta, GA September 22 – 23, 2017. EBRC members include some of the most prestigious labs in synthetic biology. Attendees will come from academic, industry, and government institutions from across the country.
Research abstracts from the Haynes lab have been selected to be showcased at the 2017 American Society for Biochemistry and Molecular Biology (ASBMB) annual meeting. ASBMB is a nonprofit scientific and educational organization with over 12,000 members. This year’s meeting will be held at McCormick Place, Chicago, IL April 22 – 26, 2017. Dr. Karmella Haynes will be presenting a talk entitled In Vitro Development of Synthetic Chromatin Proteins That Function in Live Cells on Tuesday April 25 during the Spotlight Session Beyond the Code: Chemistry of Nucleotide and Amino Acid Modifications. For the poster session Protein Engineering and Design, also on April 25th, her doctoral student Stefan Tekel (Biological Design, PhD) will present a poster entitled Using Multivalency to Improve the Function of Synthetic Epigenetic Proteins. Dr. Haynes will also be presenting a poster.
Support: NIH NCI award (K01 CA188164) to K. Haynes, SBHSE Merit Award to S. Tekel
Dr. Haynes was invited to present her research in the seminar series Recent Advances in Biology hosted by the Biology Department at Lawrence University in Appleton, Wisconsin. The organizers of Recent Advances in Biology invite select speakers from other Universities to addresses issues and advances in biological research. The presentations expose students to the latest discoveries in a wide range of biological disciplines. Dr. Haynes will present a talk on engineering proteins to control gene expression in cancer cells on Monday, April 10.
Several Haynes lab members including Cassandra Barrett, Rene Daer, David Nyer, Stefan Tekel, and Daniel Vargas will be presenting research at a 2016 Fall Retreat organized by the Engineering Biology Research Consortium (EBRC). The retreat will take place at CalTech in Pasadena, CA November 1 – 3, 2016. EBRC members include some of the most prestigious labs in synthetic biology. Attendees will come from academic, industry, and government institutions from across the country.