Review – Frontiers in Bioengineering – Can the natural diversity of quorum-sensing advance synthetic biology?
Can the natural diversity of quorum-sensing advance synthetic biology?
Davis RM, Muller RY and Haynes KA (2015) Front. Bioeng. Biotechnol. 3:30. PMID: 25806368.
Quorum sensing takes place when small molecules generated by one bacterium diffuse over to a neighbor and control that neighbor’s genes. With 100 morphologically and genetically distinct species of eubacteria that use quorum sensing to control gene expression, why does the bioengineering community only use about 4 variants to control cell communication? This review explains quorum sensing systems, their use in engineering, the problem of crosstalk between parallel QS systems, and how natural QS diversity might be used to address this problem.
- Corrigendum: Can the natural diversity of quorum-sensing advance synthetic biology? Important corrections to Figure 5, which shows conservation and variation of secondary structure motifs in quorum sensing regulator homologues.
J. Kullman, 11.10.14, ASU Now: Karmella Haynes wants to help the body fight cancer by designing proteins to stop the disease. Haynes, a synthetic biologist at Arizona State University, is leading research to explore the capability of genetically engineered proteins to reactivate tumor suppressors inside body cells to prevent the onset of cancer, or arrest its development.
Read more at ASU Now.
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N. Pierce & J. Kullman, 04.15.2013, ASU Full Circle: Arizona State University is beginning to establish its place on the map in the burgeoning field of synthetic biology. Notable strides in research are being made by faculty members and students in the School of Biological and Health Systems Engineering, one of ASU’s Ira A. Fulton Schools of Engineering. Assistant professor Karmella Haynes was recently the featured speaker on the subject of advances in synthetic biology for the Arizona Science Center’s New Frontiers in Medical Science lecture series.
Read more at ASU Full Circle.
- N. Pierce & J. Kullman, 04.13.2013, ASU News: Making strides in synthetic biology research.
- N. Pierce & J. Kullman, 04.15.2013, Bioscience Technology: Making strides in synthetic biology research.