Promise of stem cell research focus of Arizona Science Center talk

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J. Kullman, 10.16.2012, ASU News: Haynes, whose work focuses on synthetic biology, will talk about what advances in stem cell research promise for the future at 7 p.m., Nov. 2, at the Arizona Science Center.

Read more at ASU News.

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A Biological Parts Repository journey

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I’m heading back to ASU from a very mind-expanding week of leadership training, a very generous  investment in the future of synthetic biology hosted by the Sloan Foundation, NSF, SynBERC, The BioBricks Foundation, and the Woodrow Wilson Center. Twenty  emerging leaders of synthetic biology were invited to propose and develop strategic action plans [1] to advance synthetic biology in the public interest. The speakers were amazing and inspiring. I feel both fired up and focused.

This blog post marks the beginning of my synthetic biology community project, a parts registry that captures the community’s activities related to every biological part that lives in the database. I plan to draw framework structures from the big biology databases, dynamic crowd-sourced editing sites, and even social networking sites. The project will start as a series of micro-experiments where I ask the community to report their experience with a biological part or a protocol.

The repository I envision has no official name yet. But as I typed the title of this post, Biological Parts Repository or “BPR”; seemed to have potential…beeper? The acronym is short, and can be pronounced as a word that ends in a sound that makes it work as a verb (I beepered the promoter we ran those measurements on). #GuyKawasaki

  1. Haynes KA. Incentive-driven information sharing for engineering biology. http://synbioleap.org/wp-content/uploads/2013/05/incentive-driven-information-sharing-for-engineering-biology.pdf

Must a paper trail be paper?

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S. Carpenter, 09.14.2012, Science Careers: Biologist Karmella Haynes of Arizona State University, Tempe, keeps her lab notebook on OpenWetWare, one of many open-source wikis designed to serve as electronic lab notebooks.

Read more at Science Careers.

Commentary – MBoC – Synthetic meets Cell Biology

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Synthetic meets Cell Biology
Silver PA, Haynes KA, Weiss R. (2012) Mol. Biol. Cell, 23:967. PMCID: PMC3302743

In 2011 the American Society for Cell Biology Annual Meeting hosted its first minisymposium in Synthetic Cell Biology in Denver, Colorado. This exciting first for the society featured research talks on applying the concepts of synthetic biology to the understanding and engineering of cells.

Haynes brings expertise in synthetic biology to ASU’s biomedical engineering program

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N. Pierce & J. Kullman, 02.21.2012, ASU News: Haynes, who joined Arizona State University last year as an assistant professor in the School of Biological and Health Systems Engineering, one of ASU’s Ira A. Fulton Schools of Engineering, was recently elected for a two-year term as a Councilor for the Institute of Biological Engineering (IBE).

Read more at ASU News.

Research – ACS Syn Bio – A sensitive switch for visualizing natural gene silencing in single cells

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ACSsynbio2011A sensitive switch for visualizing natural gene silencing in single cells
Haynes KA, Ceroni F, Flicker D, Younger A, Silver PA. (2012) ACS Synth. Biol. 1: 99–106. PMID: 22530199

We designed a synthetic gene switch that expressed cyan fluorescent protein in the presence of microRNAs, which are biomarkers for cell development and disease. The switch was designed to be sensitive to small, hard-to-detect microRNAs in live cells. Here, we demonstrated that the switch responded to natural as well as artificial proof-of-concept microRNA signals.

Rethinking DNA and RNA

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C. Agapakis, 09.27.2011, Scientific American: Karmella Haynes, now setting up her own lab at Arizona State University, set out to not just create new sequences of DNA, but to alter how DNA is read by the cell.

Read more at Scientific American: Oscillator.