Dr. Haynes has been invited to the University of California Los Angeles (UCLA) to present a talk entitled “A pipeline to engineer synthetic epigenetic proteins derived from chromatin” for the UCLA Bioengineering Department Seminar Series on Thursday, May 17, 2018 in the Engineering V building.
Congratulations to Kimberly Olney (PhD, SOLS) who just received a 2018 Achievement Rewards for College Scientists (ARCS) Award. Kimberly is a graduate student who studies genomics and bioinformatics under the mentorship of Dr. Melissa Wilson Sayres, and has collaborated with the Haynes lab to discover genes that are controlled by synthetic chromatin regulators in breast cancer.
Congratulations to Fatima Hamna (Master’s, Biomedical Engineering) who will be joining the Haynes lab this summer with support from the new Master’s Opportunity for Research in Engineering (MORE). She will receive a stipend, materials and supplies, and the opportunity for travel support to present at a research conference.
Congratulations to Christina Smith (Undergrad, Biomedical Engineering) who will receive a stipend, materials and supplies, and an opportunity for conference travel support to complete a project in the Haynes lab this summer. Sponsorship is provided by the Fulton Undergraduate Research Initiative (FURI). This will be her second FURI award since joining the Haynes lab.
Haynes lab members Cassandra Barrett and Stefan Tekel will be presenting research at a 2018 Spring Retreat organized by the Engineering Biology Research Consortium (EBRC). The retreat will take place at the University of Washington in Seattle, WA March 23 – 24, 2018. EBRC members include some of the most prestigious labs in synthetic biology. Attendees will come from academic, industry, and government institutions from across the country.
Characterization of Diverse Homoserine Lactone Synthases in Escherichia coli
Daer R, Barrett CM, Melendez EL, Wu J, Tekel SJ, Xu J, Dennison B, Muller R, Haynes KA. (2018) PLOS ONE. doi:10.1371/journal.pone.0202294
The Haynes lab focuses on advanced chromosome engineering in human cells, but also provides opportunities for undergraduates to learn synthetic biology using simpler organisms like bacteria (E. coli). In this paper, the 2016 ASU International Genetically Engineered Machines (iGEM) Competition team and their graduate advisors report their work to identify useful, new cell-cell communication components to use in engineered systems. Homoserine lactone (HSL) synthases appear as a wide variety of different forms in the bacterial kingdom, and produce various chemical signals that regulate genes in neighboring bacteria. When these are combined to build synthetic circuits in a common lab strain (E. coli), the signals are sometimes not produced as expected. Therefore, it is important to systematically characterize HSL synthases in context. The team also used experiments to identify the most effective way to neutralize unused HSLs in biological waste. The ten HSL synthases characterized in this paper were contributed to public collections for use by the scientific community.
- Pre-print: Characterization of Diverse Homoserine Lactone Synthases in Escherichia coli. bioRxiv. https://www.biorxiv.org/content/early/2018/03/09/279349
Dr. Haynes has been invited to give seminars on her research and career as a guest of the Bruce D. Nesbitt African American Cultural Center at the University of Illinois, Urbana-Champaign. Dr. Haynes will present lectures to students across campus, as well as students at a local high school who are interested in STEM fields and the Arts on Thursday, March 1 and Friday, March 2. Dr. Haynes will present her latest breakthroughs in protein engineering for cancer research and treatment on Friday, March 2. For more information, visit https://www.facebook.com/events/2035798196678529/.