|The histone deacetylase inhibitor entinostat enhances polymer-mediated transgene expression in cancer cell lines
Elmer JJ, Christensen MD, Barua S, Lehrman J, Haynes KA, Rege K. (2015) Biotechnol Bioeng. PMID: 26614912
Collaborators from the Haynes Lab (ASU, SBHSE), Rege Lab (ASU, SEMTE), and Elmer Lab (Villanova) discovered how drugs that modify epigenetic mechanisms improve the expression of synthetic genes that are delivered into cultured human cells.
|A sensitive switch for visualizing natural gene silencing in single cells
Haynes KA, Ceroni F, Flicker D, Younger A, Silver PA. (2012) ACS Synth. Biol. 1: 99–106. PMID: 22530199
We designed a synthetic gene switch that expressed cyan fluorescent protein in the presence of microRNAs, which are biomarkers for cell development and disease. The switch was designed to be sensitive to small, hard-to-detect microRNAs in live cells. Here, we demonstrated that the switch responded to natural as well as artificial proof-of-concept microRNA signals.
|Synthetic reversal of epigenetic silencing
Haynes KA, Silver PA. (2011) J Biol Chem. 286:27176-82. PMID: 21669865
Cover article. We developed synthetic gene regulators that interact with epigenetic marks instead of DNA sequences. This research breaks new ground for artificial regulation of genes to stop cancer cell growth. The development of the synthetic chromatin protein marks the beginning of our group’s work in synthetic epigenetics. Cover art was produced by Karmella Haynes.
|Engineering bacteria to solve the burnt pancake problem
Haynes KA, Broderick ML, Brown AD, Butner TL, Dickson JO, Harden WL, Heard LH, Jessen EL, Malloy KJ, Ogden BJ, Rosemond S, Simpson S, Zwack E, Campbell AM, Eckdahl TT, Heyer LJ, Poet JL. (2008) J Biol Eng. PMID: 18492232
JBE Outstanding Publication of 2008
|A distinct type of heterochromatin within Drosophila melanogaster chromosome four
Haynes KA, Gracheva E, Elgin SC. (2006) Genetics. PMID: 17194780
|Element 1360 and RNAi components contribute to HP1-dependent silencing of a pericentric reporter
Haynes KA, Caudy AA, Collins L, Elgin SC. (2006) Current Biol. PMID: 17113386
|cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
Sun FL, Haynes K, Simpson CL, Lee SD, Collins L, Wuller J, Eissenberg JC, Elgin SC. (2004) Mol Cell Biol. PMID: 15340080
|Editorial – Synthetic Biology: Engineering Complexity and Refactoring Cell Capabilities
Ceroni F, Carbonell P, François J-M and Haynes KA (2015) Front. Bioeng. Biotechnol. 3:120. PMID: 26347864
Can the natural diversity of quorum-sensing advance synthetic biology?
Part of the research topic “Synthetic Biology: engineering complexity and refactoring cell capabilities.” Cover art by Karmella Haynes.
|Preparing synthetic biology for the world
Moe-Behrens GHG, Davis R, Haynes KA (2013) Front. Microbio. 4: 1-10. PMID: 23355834
|Synthetic meets Cell Biology
Silver PA, Haynes KA, Weiss R. (2009) MBoC. 23: 967. PMCID: PMC3302743
|Eukaryotic systems broaden the scope of synthetic biology
Haynes KA, Silver PA. (2009) J Cell Biol. PMID: 19948487